Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis
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چکیده مقاله:
Objective(s): Studies have reported that whole body vibration (WBV) played a vital role in bone remodeling. Circulating serotonin is also involved in negative regulating bone mass in rodents and humans. However, both WBV and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis in vitro . The purpose of the current study was to investigate the effect of WBV therapy on the levels of serum serotonin in ovariectomized rats. Materials and Methods: Thirty-six-month-old female Sprague Dawley rats weighing 276.15±37.75 g were ovariectomized to induce osteoporosis, and another ten rats underwent sham operation to establish sham control (SHAM) group. After 3 months, ovariectomized rats were divided into three subgroups and then separately treated with WBV, Alendronate (ALN) and normal saline (OVX), SHAM group was given normal saline. After 6 weeks of treatment, rats were sacrificed. Serum serotonin, RANKL, bone turnover markers, and bone mineral density (BMD), bone strength were evaluated. Results: The serum serotonin level was significantly lower in WBV group than OVX and ALN groups (PP
منابع مشابه
effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis
objective(s): studies have reported that whole body vibration (wbv) played a vital role in bone remodeling. circulating serotonin is also involved in negative regulating bone mass in rodents and humans. however, both wbv and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappab ligand (rankl)-induced osteoclastogenesis in vitro . the purpose of the curren...
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15 صفحه اولWhole-body vibration exercise in postmenopausal osteoporosis
The report of the World Health Organization (WHO) of 2008 defines osteoporosis as a disease characterized by low bone mass and an increased risk of fracture. Postmenopausal osteoporosis is connected to the decrease in estrogens concentration as a result of malfunction of endocrine ovarian function. Low estrogens concentration causes increase in bone demineralization and results in osteoporosis....
متن کاملEffect of Low-Magnitude Whole-Body Vibration Combined with Alendronate in Ovariectomized Rats: A Random Controlled Osteoporosis Prevention Study
BACKGROUND Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats. METHODS A total of 128 Sprague-Dawley rats were ra...
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عنوان ژورنال
دوره 17 شماره 1
صفحات 62- 68
تاریخ انتشار 2014-01-01
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