Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis

نویسندگان

  • Hai-Bin Wang 2Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
  • Li Huang 1Department of Rehabilitation, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
  • Shao Chuan Huo. 2Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
  • Wei-Min Deng 1Department of Rehabilitation, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
  • Wei-Shan Sun 1Department of Rehabilitation, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
  • Xian Hong Chen 1Department of Rehabilitation, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
  • Zi Qi Li 2Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
چکیده مقاله:

  Objective(s): Studies have reported that whole body vibration (WBV) played a vital role in bone remodeling. Circulating serotonin is also involved in negative regulating bone mass in rodents and humans. However, both WBV and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis in vitro . The purpose of the current study was to investigate the effect of WBV therapy on the levels of serum serotonin in ovariectomized rats.   Materials and Methods: Thirty-six-month-old female Sprague Dawley rats weighing 276.15±37.75 g were ovariectomized to induce osteoporosis, and another ten rats underwent sham operation to establish sham control (SHAM) group. After 3 months, ovariectomized rats were divided into three subgroups and then separately treated with WBV, Alendronate (ALN) and normal saline (OVX), SHAM group was given normal saline. After 6 weeks of treatment, rats were sacrificed. Serum serotonin, RANKL, bone turnover markers, and bone mineral density (BMD), bone strength were evaluated. Results: The serum serotonin level was significantly lower in WBV group than OVX and ALN groups (PP

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis

objective(s): studies have reported that whole body vibration (wbv) played a vital role in bone remodeling. circulating serotonin is also involved in negative regulating bone mass in rodents and humans. however, both wbv and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappab ligand (rankl)-induced osteoclastogenesis in vitro . the purpose of the curren...

متن کامل

: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes

هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...

Whole-body vibration exercise in postmenopausal osteoporosis

The report of the World Health Organization (WHO) of 2008 defines osteoporosis as a disease characterized by low bone mass and an increased risk of fracture. Postmenopausal osteoporosis is connected to the decrease in estrogens concentration as a result of malfunction of endocrine ovarian function. Low estrogens concentration causes increase in bone demineralization and results in osteoporosis....

متن کامل

Effect of Low-Magnitude Whole-Body Vibration Combined with Alendronate in Ovariectomized Rats: A Random Controlled Osteoporosis Prevention Study

BACKGROUND Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats. METHODS A total of 128 Sprague-Dawley rats were ra...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 17  شماره 1

صفحات  62- 68

تاریخ انتشار 2014-01-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023